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** Dataset: manually curated Human Signaling Network dataset (Updated April, 2013, HumanSignalingNetwork_v5.txt, ~6,300 proteins and ~63,000 relations). ** New Book: Wang E (ed), Cancer Systems Biology, CRC Mathematical and Computational Biology Series, 2010 [Link]. ** Internal computational tools and data resources (password is required) |
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Selected Publications
- The human phosphotyrosine signaling network-evolution and hotspots of hijacking in cancer.
Lei Li, Chabane Tibiche, Cong Fu, Tomonori Kaneko, Michael Moran, Martin Schiller, Shawn Li & Edwin Wang.
Genome Research, 22:1222–1230, 2012
The paper is freely available in Genome Research.
- Identification of high-quality cancer prognostic markers and metastasis network modules.
Li J, Lenferink AE, Deng Y, Cantin C, Cui Q, Purisima EO, O'Connor-McCourt MD, Wang E.
Nature Communications, 1:34, 2010
The paper is freely available in Nature Communications. Highlighted in GenomeWeb-This Week in Nature [HTML]; also in SciBX: Science-Business eXchange, 2010 [HTML]; also in GEN's Tech Tips: Protein Biomarker Discovery, 2010 [PDF] A pratical protocol of the algorithm [Protocol] [Software]
- A map of human cancer signaling.
Cui, Q., Ma, Y., Jaramillo, M., Bari, H., Awan, A., Yang, S., Zhang, S., Liu, L., Lu, M., O'Connor-McCourt, M., Purisima, E. and Wang, E.
Nature-EMBO Molecular Systems Biology, 3:152, 2007
Abstract , human signaling network dataset , cancer-signaling-map dataset, and access the paper in MSB, a new journal from EMBO and Nature. Highlighted in Genome Technology Magazine [PDF]. Selected by NRC Highlights [webLink]. News in Genomics and Proteomics [PDF]. Selected in Highlight Track, 16th International Conference of ISMB, 2008 [Presentation in Nature Precedings].
- MicroRNA regulation and interspecific variation of gene expression.
Qinghua Cui, Zhenbao Yu, Enrico Purisima and Edwin Wang
Trends Genet., 23:372-375, 2007
Abstract , paper and supplementary materials.
- Principles of microRNA regulation of a human cellular signaling network.
Qinghua Cui, Zhenbao Yu, Enrico Purisima and Edwin Wang
Nature-EMBO Molecular Systems Biology, 2:46, 2006
Supplementary materials and access the paper in MSB, a new journal from EMBO and Nature.
- Network motifs are enriched with transcription factors
whose transcripts have short half-lives.
Edwin Wang and Enrico Purisima
Trends Genet., 21:492-495, 2005
Abstract , paper and supplementary materials.
Reviews
- Cancer systems biology in the genome sequencing era: Part 2, evolutionary dynamics of tumor clonal networks and drug resistance (Invited Review).
Wang E, Zou J, Zaman N, Beitel KL, Trifiro M and Paliouras M.
Seminars in Cancer Biology, 2013 [Paper]
- Cancer systems biology in the genome sequencing era: Part 1, dissecting and modeling of tumor clones and their networks (Invited Review).
Wang E, Zou J, Zaman N, Beitel KL, Trifiro M and Paliouras M.
Seminars in Cancer Biology, 2013 [Paper]
- Understanding genomic alterations in cancer genomes using an integrative network approach (Invited Review).
Wang Edwin
Cancer Letter, in press, 2012 [Paper]
- Dynamic modeling and analysis of cancer cellular network motifs.
Cloutier and Wang.
Integrative Biology, 3:724-732, 2011 (Invited Review) [Paper] // [Supplementary Methods]
- A roadmap of cancer systems biology.
Edwin Wang
Cancer Systems Biology (Wang, E. ed), Chapman & Hall/CRC Press, 2010 [PDF]
- Cancer systems biology: exploring cancer-associated genes on cellular networks.
Wang, E., Lenferink, AE.,and O'Connor-McCourt, MD.
Cellular and Molecular Life Sciences (CMLS), 64:1752-1762, 2007, [invited review] [PDF]
- More publications and lab information: enter here.
- Tumor geneome sequencing paper track: enter here.